The move to Southern Hills marks the fifth time the club will play host to the tournament, the most recent being in 2007 when Tiger Woods won by two strokes over Woody Austin.
It will be the fifth PGA conducted at Southern Hills, the first since 2007. The course has also hosted three US Opens and two US Amateurs, and will serve as home to the 2021 Senior PGA next May.
The PGA of America will be moving its flagship event, the PGA Championship, from its traditional August date on the golf calendar to May, sources familiar with the decision confirmed to Golf Digest.